Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation.
Fakuade FE, Hubricht D, Möller V, Sobitov I, Liutkute A, Döring Y, Seibertz F, Gerloff M, Pronto JRD, Haghighi F, Brandenburg S, Alhussini K, Ignatyeva N, Bonhoff Y, Kestel S, El-Essawi A, Jebran AF, Großmann M, Danner BC, Baraki H, Schmidt C, Sossalla S, Kutschka I, Bening C, Maack C, Linke WA, Heijman J, Lehnart SE, Kensah G, Ebert A., Mason FE, Voigt N.
Circulation. 2024 Aug 13;150(7):544-559. doi: 10.1161/CIRCULATIONAHA.123.066577. Epub 2024 Jun 24.
PMID: 38910563

3D Computational Modeling of Defective Early Endosome Distribution in Human iPSC-Based Cardiomyopathy Models.
Saleem HN, Ignatyeva N, Stuut C, Jakobs S, Habeck M, Ebert A.
Cells. 2024 May 27;13(11):923. doi: 10.3390/cells13110923.
PMID: 38891055

Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy.
Wali R, Xu H, Cheruiyot C, Saleem HN, Janshoff A, Habeck M, Ebert A.
Biol Chem. 2024 Apr 24;405(6):427-439. doi: 10.1515/hsz-2024-0023. Print 2024 Jun 25.
PMID: 38651266

An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes.
Dai Y, Ignatyeva N, Xu H, Wali R, Toischer K, Brandenburg S, Lenz C, Pronto J, Fakuade FE, Sossalla S, Zeisberg EM, Janshoff A, Kutschka I, Voigt N, Urlaub H, Rasmussen TB, Mogensen J, Lehnart SE, Hasenfuss G, Ebert A.
Circ Res. 2023 Jul 7;133(2):e19-e46. doi: 10.1161/CIRCRESAHA.122.321157. Epub 2023 Jun 14.
PMID: 37313752

Increased cytosolic calcium buffering contributes to a cellular arrhythmogenic substrate in iPSC-cardiomyocytes from patients with dilated cardiomyopathy.
Jung P, Seibertz F, Fakuade FE, Ignatyeva N, Sampathkumar S, Ritter M, Li H, Mason FE, Ebert A, Voigt N.
Basic Res Cardiol. 2022 May 2;117(1):5. doi: 10.1007/s00395-022-00912-z.
PMID: 35499658

Signal transduction in health and disease.
Ebert A.
Biol Chem. 2021 Dec 24;403(2):131. doi: 10.1515/hsz-2021-0432.
PMID: 34958533

Non-negative blind deconvolution for signal processing in a CRISPR-edited iPSC-cardiomyocyte model of dilated cardiomyopathy.
Xu H, Wali R, Cheruiyot C, Bodenschatz J, Hasenfuss G, Janshoff A, Habeck M, Ebert A.
FEBS Lett. 2021 Oct;595(20):2544-2557. doi: 10.1002/1873-3468.14189. Epub 2021 Sep 17.
PMID: 34482543

Integrated Ca2+ flux and AFM force analysis in human iPSC-derived cardiomyocytes.
Malkovskiy AV, Ignatyeva N, Dai Y, Hasenfuss G, Rajadas J, Ebert A.
Biol Chem. 2020 Oct 27;402(1):113-121. doi: 10.1515/hsz-2020-0212. Print 2020 Nov 18.
PMID: 33544492

Human-induced pluripotent stem cells as models for rare cardiovascular diseases: from evidence-based medicine to precision medicine.
Pan Z, Ebert A, Liang P.
Pflugers Arch. 2021 Jul;473(7):1151-1165. doi: 10.1007/s00424-020-02486-y. Epub 2020 Nov 18.
PMID: 33206225 Review.

Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients.
Dai Y, Amenov A, Ignatyeva N, Koschinski A, Xu H, Soong PL, Tiburcy M, Linke WA, Zaccolo M, Hasenfuss G, Zimmermann WH, Ebert A.
Sci Rep. 2020 Jan 14;10(1):209. doi: 10.1038/s41598-019-56597-3. PMID: 31937807

Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes.
Ebert A*, Joshi AU, Andorf S, Dai Y, Sampathkumar S, Chen H, Li Y, Garg P, Toischer K, Hasenfuss G, Mochly-Rosen D, Wu JC*.
Circ Res. 2019 Jun 21;125(1):90-103. doi: 10.1161/CIRCRESAHA.118.313973. Epub 2019 May 20. PMID: 31104567 *corresponding author

Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.
Joshi AU, Ebert A, Haileselassie B, Mochly-Rosen D.
J Mol Cell Cardiol. 2019 Feb;127:125-133. doi: 10.1016/j.yjmcc.2018.12.004. Epub 2018 Dec 11. PMID: 30550751

Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix.
Lee AS, Inayathullah M, Lijkwan MA, Zhao X, Sun W, Park S, Hong WX, Parekh MB, Malkovskiy AV, Lau E, Qin X, Pothineni VR, Sanchez-Freire V, Zhang WY, Kooreman NG, Ebert AD, Chan CKF, Nguyen PK, Rajadas J, Wu JC.
Nat Biomed Eng. 2018 Feb;2(2):104-113.

Paracrine Effects of the Pluripotent Stem Cell-Derived Cardiac Myocytes Salvage the Injured Myocardium.
Tachibana A, Santoso MR, Mahmoudi M, Shukla P, Wang L, Bennett M, Goldstone AB, Wang M, Fukushi M, Ebert AD, Woo YJ, Rulifson E, Yang PC.
Circ Res. 2017 Sep 1;121(6):e22-e36. doi: 10.1161/CIRCRESAHA.117.310803. Epub 2017 Jul 25.

Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome.
Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC.
J Am Coll Cardiol. 2016 Nov 8;68(19):2086-2096

iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy. Kodo K, Ong SG, Jahanbani F, Termglinchan V, Hirono K, InanlooRahatloo K, Ebert AD, Shukla P, Abilez OJ, Churko JM, Karakikes I, Jung G, Ichida F, Wu SM, Snyder MP, Bernstein D, Wu JC. Nat Cell Biol. 2016 Oct;18(10):1031-42

Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC. Nat Med. 2016 May;22(5):547-56

Microfluidic Single-Cell Analysis of Transplanted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes After Acute Myocardial Infarction. Ong SG, Huber BC, Lee WH, Kodo K, Ebert AD, Ma Y, Nguyen PK, Diecke S, Chen WY, Wu JC. Circulation. 2015 Aug 25;132(8):762-71.

Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model. Riegler J, Tiburcy M, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen VC, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH, Wu JC. Circ Res. 2015 Sep 25;117(8):720-30

Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand? Ebert AD, Diecke S, Chen IY, Wu JC. EMBO Mol Med. 2015 Jul 16;7(9):1090-103. doi: 10.15252/emmm.201504395. Review.

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system.
Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC. Sci Transl Med. 2014 Sep 24;6(255):255ra130.

Chemically defined generation of human cardiomyocytes. Burridge PW, Matsa E, Shukla P, Lin ZC, Churko JM, Ebert AD, Lan F, Diecke S, Huber B, Mordwinkin NM, Plews JR, Abilez OJ, Cui B, Gold JD, Wu JC. Nat Methods. 2014 Aug;11(8):855-60

Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Lan F, Lee AS, Liang P, Sanchez-Freire V, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Hu S, Ebert AD, Navarrete EG, Simmons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Robbins RC, Longaker MT, Wu JC. Cell Stem Cell. 2013 Jan 3;12(1):101-13

Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns. Sanchez-Freire V, Ebert AD, Kalisky T, Quake SR, Wu JC. Nat Protoc. 2012 Apr 5;7(5):829-38

Induced pluripotent stem cells as a disease modeling and drug screening platform. Ebert AD, Liang P, Wu JC. J Cardiovasc Pharmacol. 2012 Oct;60(4):408-16. doi: 10.1097/FJC.0b013e318247f642. Review.

Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Ebert AD, Laussmann M, Wegehingel S, Kaderali L, Erfle H, Reichert J, Lechner J, Beer HD, Pepperkok R, Nickel W. Traffic. 2010 Jun;11(6):813-26

A direct role for phosphatidylinositol-4,5-bisphosphate in unconventional secretion of fibroblast growth factor 2. Temmerman K, Ebert AD, Müller HM, Sinning I, Tews I, Nickel W. Traffic. 2008 Jul;9(7):1204-17